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CYTORA at BioMed Israel 2025: Harnessing the unique potential of human oral mucosa stem cell (hOMSC) for treating complex multifactorial diseases.

21 May 2025

Dr. Yona Geffen, CEO of Cytora presented how the unique potential of human oral mucosa stem cells (hOMSC) to treating multifactorial diseases as part of the Genetic and Cellular Advances for Rare and Complex Diseases session. hOMSC are a unique population of stem cells originating from the neural crest. In the oral cavity, they mediate rapid wound healing compared to other tissues, promote full tissue regeneration, without scarring, and their activity is not affected by age. hOMSC are easily propagated without losing their unique stem-cell properties – a tiny biopsy of 4x3x2 mm from a healthy donor generates doses for thousands of doses. thus, enabling the production of an “off the shelf” stem cell treatment platform for human use. Results of Cytora’s two clinical programs phase 1/2a for DFU and phase 1 ongoing study for MSA were presented.

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Cytora’s patented platform technology is based on the discovery of a novel and unique stem cell population in the human oral mucosa (hOMSC), the origin of which is the embryonic nervous system. hOMSC are endowed with properties of neural crest, neural and mesenchymal stem cells. Cytora’s products are allogeneic, off-the-shelf, easily scalable, with a very competitive cost of goods (COG). The products were found to be safe and effective in early phase clinical trials in two indications: Diabetic Foot Ulcers (DFU) and Multiple System Atrophy (MSA).

Our products have high potential for treating complicated multifactorial diseases such as chronic and neurodegenerative diseases, incurable wounds and autoimmune diseases.

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