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​Stem cells are revolutionizing the treatment of incurable diseases

Potential

Naïve stem cells can dynamically adapt to their surrounding tissues and influence the cellular microenvironment, giving them the potential to treat, attenuate, or halt the progression of complex, multifactorial, and chronic diseases.

Problem

Current therapies have limitations of efficacy, scalability and cost. 

Opportunity

Based on the discovery of hOMSC by Prof. Pitaru at Tel-Aviv University, Cytora leveraged hOMSC as a unique naïve stem cell population with inherent neural properties to develop effective, safe, and scalable off-the-shelf products for chronic and neurodegenerative diseases. 

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Harnessing the Power of hOMSC

Taking origin from the embryonic brain, hOMSC retain properties of neural crest stem cells capable of supporting neural tissues and influencing neurodegenerative disease processes. hOMSC integrate within the affected tissue and remain functional for a few months.

Cytora’s products have special abilities to treat hard-to-heal diabetic wounds such as Diabetic Foot Ulcer (DFU), and Neurodegenerative diseases such as Multiple System Atrophy (MSA), Parkinson’s Disease, Alzheimer’s Disease and autoimmune diseases.

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hOMSC
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The Ultra Potent Neural Crest Stem Cells

Discovery
High expandability

High expandability  

A tiny biopsy of 4x3x2 mm hOMSC  from a healthy donor generates  therapeutic doses for thousands of sick people, a prerequisite for the production of large batches for “off-the-shelf” products.

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Robust and efficient reproducibility

Robust, efficient and cost-effective expandability

A simple culture medium with a simple production process produces comparable results across donors, irrespective of age or gender.

Robust GMP production line capable of producing therapeutic doses for thousands of patients. 

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Allogeneic immune properties

Allogeneic immune properties

Naïve allogeneic hOMSC do not trigger cellular or humoral immune responses upon transplantation. Therefore, hOMSC can be suitable for use as allogeneic "off-the-shelf" products.

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Potency & safety

Potency & safety - a unique combination 

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hOMSC combine the high potency of primitive stem cells combined with a high safety profile of adult stem cells (non-tumorigenic, non-immunogenic).

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Cytora’s patented platform technology is based on the discovery of a novel and unique stem cell population in the human oral mucosa (hOMSC), the origin of which is the embryonic nervous system. hOMSC are endowed with properties of neural crest, neural and mesenchymal stem cells. Cytora’s products are allogeneic, off-the-shelf, easily scalable, with a very competitive cost of goods (COG). The products were found to be safe and effective in early phase clinical trials in two indications: Diabetic Foot Ulcers (DFU) and Multiple System Atrophy (MSA).

Our products have high potential for treating complicated multifactorial diseases such as chronic and neurodegenerative diseases, incurable wounds and autoimmune diseases.

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